Tribology and Materials | Volume 3 | Issue 2 | 2024 | 81-95
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https://doi.org/10.46793/tribomat.2024.009
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Review of the 3D bioprinting methods and materials applicable in 4D bioprinting
Masukur Rahman
1,
Salman Al-hossain Prodhan1,
Rayhanul Islam1,
Ashik Mahmud1,
Khan Rajib Hossain
2
1 Faculty of Engineering, University of Rajshahi, Rajshahi, Bangladesh
2 Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China
Abstract: The advent of 4D bioprinting, a technique that
integrates time dimensions into the conventional 3D method,
substantially changed tissue engineering. By providing a time dimension
to conventional 3D printing, the innovative process of 4D bioprinting is
revolutionising tissue engineering. This development allows the creation
of dynamic tissues, allowing structures to change and adapt over time to
reflect the complexity of natural tissues. Specifically, shape memory
polymers enable customised scaffold fabrication with improved mechanical
strength and biomimicry for use in bone tissue engineering. An essential
additional use for soft tissue regeneration is the development of
injectable thermosensitive hydrogels that react to body temperature.
Within asymmetrical defect regions, these hydrogels gel, offering a
flexible cure for healing injured soft tissues. In addition to
structural considerations, the potential applications of 4D bioprinting
include organisms, vascularisation and dynamic disease models. Despite
the advancements, issues like suitable biocompatibility and long-term
stability still need to be resolved. However, by creating complex,
adaptable and patient-specific designs in the realm of tissue
engineering, 4D bioprinting has enormous potential to transform
personalised medicine and regenerative therapies. This review provides a
comprehensive investigation into the future of regenerative medicine by
exploring the various uses and potentially revolutionary effects of 4D
bioprinting in tissue engineering.
Keywords:
tissue engineering, bioprinting, 4D printing, mechanical metamaterials.
Received: 24-04-2024, Revised: 19-06-2024, Accepted: 27-06-2024
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license, which allows users to distribute, remix, adapt,
and build upon the material in any medium or format for non-commercial purposes only, and only so long as attribution is given to the creator.
2 Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China
Abstract: The advent of 4D bioprinting, a technique that integrates time dimensions into the conventional 3D method, substantially changed tissue engineering. By providing a time dimension to conventional 3D printing, the innovative process of 4D bioprinting is revolutionising tissue engineering. This development allows the creation of dynamic tissues, allowing structures to change and adapt over time to reflect the complexity of natural tissues. Specifically, shape memory polymers enable customised scaffold fabrication with improved mechanical strength and biomimicry for use in bone tissue engineering. An essential additional use for soft tissue regeneration is the development of injectable thermosensitive hydrogels that react to body temperature. Within asymmetrical defect regions, these hydrogels gel, offering a flexible cure for healing injured soft tissues. In addition to structural considerations, the potential applications of 4D bioprinting include organisms, vascularisation and dynamic disease models. Despite the advancements, issues like suitable biocompatibility and long-term stability still need to be resolved. However, by creating complex, adaptable and patient-specific designs in the realm of tissue engineering, 4D bioprinting has enormous potential to transform personalised medicine and regenerative therapies. This review provides a comprehensive investigation into the future of regenerative medicine by exploring the various uses and potentially revolutionary effects of 4D bioprinting in tissue engineering.
Keywords: tissue engineering, bioprinting, 4D printing, mechanical metamaterials.
Received: 24-04-2024, Revised: 19-06-2024, Accepted: 27-06-2024
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license, which allows users to distribute, remix, adapt, and build upon the material in any medium or format for non-commercial purposes only, and only so long as attribution is given to the creator.